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autophagy, autophagosome

Term: autophagy

Origin: Anc   Greek
αυτός/autos(=self)
φάγω/phago(=to eat)
σώμα/soma(=body)

Coined:
Christian de Duve 1917-
In 1963 by Belgian cytologist and biochemist  Christian de Duve after his discovery of lysosomes, in order to create a nomenclature for different cellular pathways and compartments in the endosomal-lysomal pathway.

Definition:
The catabolic process of self-digestion through the lysosomal machinery including degradation of proteins and organelles, cellular remodeling, and survival during nutrient starvation. Autophagy starts with the formation of a vacuole, known as autophagosome.

2 comments:

  1. Hello,

    You have provided a very good site to knowing about Autophagy. It is a tightly regulated process that plays a normal part in cell growth, development, and homeostasis helping to maintain a balance between the synthesis, degradation and subsequent recycling of cellular products...

    ReplyDelete

  2. prof premraj pushpakaran writes -- 2017 marks the 100th birth year of Christian de Duve!!!

    ReplyDelete

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